Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival
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چکیده
منابع مشابه
Constitutive Nuclear Factor- B Activity Is Required for Central Neuron Survival
The function of nuclear factor (NF)B within the developing and mature CNS is controversial. We have generated transgenic mice to reveal NFB transcriptional activity in vivo. As expected, constitutive NFB activity was observed within immune organs, and tumor necrosis factor-inducible NFB activity was present in mesenchymal cells. Intriguingly, NFB activity was also prominent in the CNS throughou...
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The pathogenesis and etiology of Hodgkin's disease, a common human malignant lymphoma, is still unresolved. As a unique characteristic, we have identified constitutive activation of the transcription factor nuclear factor (NF)-kappaB p50-RelA in Hodgkin/Reed-Sternberg (H/RS) cells, which discriminates these neoplastic cells from most cell types studied to date. In contrast to other lymphoid and...
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The expression of normal cellular prion protein (PrP) is required for the pathogenesis of prion diseases. However, the physiological functions of PrP remain ambiguous. Here, we identified PrP as being critical for tumor necrosis factor (TNF) α-triggered signaling in a human melanoma cell line, M2, and a pancreatic ductal cell adenocarcinoma cell line, BxPC-3. In M2 cells, TNFα up-regulates the ...
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Although immunoglobulin (Ig)M(hi)IgD(lo/-)CD21(hi) marginal zone B cells represent a significant proportion of naive peripheral splenic B lymphocytes, few of the genes that regulate their development have been identified. This subset of peripheral B cells fails to emerge in mice that lack nuclear factor (NF)-kappa Bp50. Less drastic reductions in marginal zone B cell numbers are also seen in th...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2002
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.22-19-08466.2002